1. Call the CLOZARIL National Registry (CNR) to obtain a rechallenge number and to confirm that you and your pharmacy are registered.
2. Obtain a baseline WBC with ANC from patient. If within normal limits, WBC >= 3500/mm³, ANC >= 2000/mm³, prescribe CLOZARIL tablets.
3. Submit WBC and ANC information to the registered pharmacy.
4. Please be prepared to provide your DEA # to the CNR when you are registered for the first time.

*Optional Subsequent dosage increments should be made no more than once or twice weekly, in increments not to exceed 100 mg.

References: 1. Meltzer HY. Treatment of the neuroleptic nonresponsive schizophrenic patient. Schizophr Bull. 1992;18(3):515-542. 2. CLOZARIL Prescribing Information. Novartis Pharmaceuticals Corporation.

To download the dosing guide click here.